Full Citation
Title: Trends in Use of Oral Emtricitabine/Tenofovir Disoproxil Fumarate for Pre-Exposure Prophylaxis Against HIV Infections, United States, 2012-2017
Citation Type: Journal Article
Publication Year: 2018
ISBN:
ISSN:
DOI: https://doi.org/10.1016/j.annepidem.2018.06.009
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PMCID:
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Abstract: Background Pre-exposure prophylaxis (PrEP) with oral TDF/FTC reduces the risk of HIV infection by >90% when taken as prescribed. Trends in prevalence of PrEP use, which account for persons who have stopped PrEP, increased through 2016, but have not been described since. Methods Annual prevalence estimates of unique, TDF/FTC PrEP users (individuals with ≥1 day of PrEP prescribed in a given year) in the United States (US) were generated for 2012-2017 from a national prescription database. A validated algorithm was used to distinguish users of TDF/FTC for HIV or Hepatitis B treatment or post-exposure prophylaxis from PrEP users. We calculated annual prevalence of PrEP use overall and by age, sex and region. We used log-transformation to calculate estimated annual percent change (EAPC) in the prevalence of PrEP use. Results Annual prevalence of PrEP use increased from 3.3/100,000 population in 2012 to 36.7 in 2017 –a 56% annual increase from 2012-2017 (EAPC: +56%). Annual prevalence of PrEP use increased faster among men than among women (EAPC: +68% and +5%, respectively). By age group, annual prevalence of PrEP use increased fastest among 25-34 year olds (EAPC: +61%) and slowest among ≥55 year olds (EAPC: +52%) and ≤24 year olds (EAPC: +51%). By region, in 2017 prevalence PrEP use was lowest in the South (29.8/100,000) and highest in the Northeast (62.3/100,000) Conclusions Despite overall increases in the annual number of TDF/FTC PrEP users in the US from 2012-2017, the growth of absolute PrEP coverage is inconsistent across groups. Efforts to optimize PrEP access are especially needed for women and for those living in the South.
Url: https://www.sciencedirect.com/science/article/pii/S1047279718301066
User Submitted?: No
Authors: Sullivan, Patrick, S; Giler, Robertino Mera; Mouhanna, Farah; Pembleton, Elizabeth; Guest, Jodie; Jones, Jeb; Astel, Amanda; Yeung, Howa; Kramer, Michael; McCallister, Scott; Siegler, Aaron
Periodical (Full): Annals of Epidemiology
Issue: 12
Volume: 28
Pages: 833-840
Data Collections: IPUMS NHGIS
Topics: Health, Other, Population Health and Health Systems
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