Full Citation

Title: The use of genealogy databases for risk assessment in genetic health service: a systematic review

Citation Type: Journal Article

Publication Year: 2013

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Abstract: The use of electronic genealogical databases facilitates the construction of accurate and extensive pedigrees for potential use in genetic services. Genealogy databasescan be linked to specific disease databases, such as cancer registries, in order to increase the accuracy of pedigreesused, and inform the genetic risk assessment. To review the published literature on the use of genealogy databases to construct pedigrees for risk assessment in genetic health service, a systematic literature search was undertaken using 12 combined search terms to identify all relevant published articles. Data sources: EbscoHost, PubMed, Web of Science, Ovid and the grey literature, as well as the reference lists of identified studies. Of 1,035 titles identified, two papers described a study on the use ofgenealogy databases in cancer risk assessment and two werediscussion papers. While authors of the four papers described the potential use of genealogy databases in clinical genetic services, such use has not been adequatelyinvestigated and further research is required.

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Authors: Tulinius, Hrafn; Skirton, Heather; Stefansdottir, Vigdis; Jonsson, Jon J.; Tryggvadottir, Laufey; Johannsson, Oskar

Periodical (Full): Journal of Community Genetics

Issue: 1

Volume: 4

Pages: 1-7

Data Collections: IPUMS USA

Topics: Health, Other

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