Full Citation

Title: Acute lymphoblastic leukemia mortality in Hispanic Americans

Citation Type: Journal Article

Publication Year: 2020

ISBN:

ISSN: 10292403

DOI: 10.1080/10428194.2020.1779260

NSFID:

PMCID:

PMID: 32568614

Abstract: Higher incidence and poorer outcomes of acute lymphoblastic leukemia (ALL) in Hispanic Americans have been attributed to high-risk molecular markers associated with Native American (NA) ancestry. However, the diverse Hispanic populations in the United States differ substantially in ancestry. Continental Hispanics have a high proportion of NA ancestry while Caribbean Hispanics have a lower proportion of NA ancestry. Here, we analyzed mortality data of 2428 children and adults with ALL. Mortality rates were age-adjusted and compared by race and ethnicity using negative binomial regression with particular attention to distinct Hispanic populations. While both Continental (mortality rate ratio (MRR) 2.09, 95% CI 1.82–2.39) and Caribbean (MRR 1.27, 95% CI 1.05–1.54) Hispanics had higher mortality rates than other racial and ethnic groups, Continental Hispanics had significantly higher mortality rates than Caribbean Hispanics. This is the first study to demonstrate a clear difference in ALL mortality by Hispanic group on a population basis.

Url: https://www.tandfonline.com/doi/abs/10.1080/10428194.2020.1779260

User Submitted?: No

Authors: Shoag, Jamie M.; Barredo, Julio C.; Lossos, Izidore S.; Pinheiro, Paulo S.

Periodical (Full): Leukemia & Lymphoma

Issue: 11

Volume: 61

Pages: 2674-2681

Data Collections: IPUMS USA

Topics: Health, Race and Ethnicity

Countries: