Full Citation

Title: Acute Leukemia in Adult Hispanic Americans: Differences in Incidence Rates by Nativity

Citation Type: Journal Article

Publication Year: 2014

ISBN:

ISSN:

DOI: 10.15406/jcpcr.2014.01.00005

NSFID:

PMCID:

PMID:

Abstract: The incidence pattern of adult acute leukemia (AL) in Hispanics is distinct, with increased B-cell acute lymphoblastic leukemia (ALL) and acute promyelocytic leukemia (APL) and decreased non-APL acute myeloid leukemia (AML). To better understand genetic versus environmental contributors, we assessed AL incidence rates in a population of adult California Hispanics according to birthplace. Using data from California AL patients ≥20 diagnosed between 2000-2009, incidence rate ratios (IRR) were employed to compare incidence rates of AL in foreign- versus United States (US)-born Hispanics. Compared to whites, Hispanics had increased incidence rates of B-cell ALL and APL, IRR2.13 (1.93-2.35) and 1.33 (1.12-1.57), respectively. No nativity differences in B-cell ALL were noted. Foreign-born Hispanics had a higher incidence rate of APL versus US-born Hispanics (IRR 1.79, 1.11-2.94). For adult Hispanics, increased B-cell ALL incidence rates may be due to heritable genetic factors; increased APL incidence rates may be due to as yet unknown environmental exposures.

Url: https://pdfs.semanticscholar.org/955a/191dbdf58b856cae197f83c93b834113e33e.pdf

User Submitted?: No

Authors: Pollyea, Daniel A.; Kohrt, Holbrook E.; Yang, Juan; Chang, Ellen T.; Gomez, Scarlett Lin; Clarke, Christina A.

Periodical (Full): Journal of Cancer Prevention & Current Research

Issue: 1

Volume: 1

Pages: 7

Data Collections: IPUMS USA

Topics: Health, Other, Population Health and Health Systems

Countries: