Full Citation

Title: Seroprevalence of Antibodies Specific to Receptor Binding Domain of SARS-CoV-2 and Vaccination Coverage Among Adults in Los Angeles County, April 2021: The LA Pandemic Surveillance Cohort Study

Citation Type: Journal Article

Publication Year: 2022

ISBN:

ISSN: 2574-3805

DOI: 10.1001/jamanetworkopen.2021.44258

NSFID:

PMCID:

PMID:

Abstract: This cross-sectional study was approved by the LAC Department of Public Health (DPH) institutional review board and electronic informed consent was obtained. This study follows the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) reporting guideline. We tested for RBD antibodies using an FDA emergency use authorized assay (Luminex xMAP SARS-CoV-2). We established 8 testing sites in LAC and residents who lived within a 15-mile radius (99% of LAC population) were eligible for participation. Testing was offered from April 9 to April 25, 2021. We used a proprietary database representing about a quarter of the LAC population maintained by a market research firm (LRW Group, a Material Company), to select participants. A random sample of these residents were invited, with quotas for enrollment for subgroups based on demographics of LAC residents. All participants were invited to participate in antibody testing and participants self-selected to consent for testing. Participants who had participated in a similar study conducted in April 2020 were oversampled.6 Weights were used to adjust results for LAC 2019 census estimates of demographics and LAC DPH data on confirmed COVID-19 cases and COVID-19 vaccination rates by race and ethnicity, age, and gender. Data on race and ethnicity were self reported by residents; race and ethnicity data were collected to document disparities in rate of potential protective immunity by race and ethnicity. We used these weighted data to estimate the fraction of LAC adults that had received at least 1 dose of vaccine or had RBD antibodies, as a whole, and by vaccination status, demographics, and area poverty level. Statistical analysis was performed using Stata version 15 (StataCorp) from April to November 2021.

Url: https://doi.org/10.1001/jamanetworkopen.2021.44258

User Submitted?: No

Authors: Sood, Neeraj; Pernet, Olivier; Lam, Chun Nok; Klipp, Angela; Kotha, Rani; Kovacs, Andrea; Hu, Howard

Periodical (Full): JAMA Network Open

Issue: 1

Volume: 5

Pages: e2144258

Data Collections: IPUMS USA

Topics: Health

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