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Title: Duke Twins Study of Memory in Aging in the NAS-NRC Twin Registry

Citation Type: Journal Article

Publication Year: 2006

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Abstract: The Duke Twins Study of Memory in Aging is anongoing, longitudinal study of cognitive changeand dementia in the population-based NationalAcademy of Sciences-National Research Council(NAS-NRC) Twin Registry of World War II MaleVeterans. The primary goal of this study has beento estimate the overall genetic and environmentalcontributions to dementia with a specific focus onAlzheimers disease. An additional goal has beento examine specific genetic and environmentalantecedents of cognitive decline and dementia.Since 1989, we have completed 4 waves of datacollection. Each wave included a 2-phase telephonecognitive screening protocol, followed byan in-home standardized clinical assessment forthose with suspected dementia. For many participants,we have obtained postmortem neuropathologicalconfirmation of the diagnosis ofdementia. In addition to data on cognition, wehave also collected information on occupationalhistory, medical history, medications and otherlifetime experiences that may influence cognitivefunction in late life. We provide an overview of thestudys methodology and describe the focus ofrecent research.

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Authors: Burke, James R.; Plassman, Brenda L.; Newman, Tiffany N.; Welsh-Bohmer, Kathleen A.; Steffens, David C.; Drosdick, Deborah

Periodical (Full): Twin Research and Human Genetics

Issue: 6

Volume: 9

Pages: 950-957

Data Collections: IPUMS USA

Topics: Labor Force and Occupational Structure

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