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Title: Hodgkin lymphoma incidence in California Hispanics: Influence of nativity and tumor Epstein-Barr virus
Citation Type: Journal Article
Publication Year: 2014
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Abstract: PurposeFor classical Hodgkin lymphoma (HL), migrant studies could elucidate contributions of environmental factors (including EpsteinBarr virus (EBV)) to the lower rates in non-whites. Given the well-described etiologic complexity of HL, this research requires a large, immigrant population, such as California Hispanics.MethodsWith 19882004 California Cancer Registry data (2,595 Hispanic, 8,637 white HL cases) and tumor cell EBV status on a subset (218 Hispanics, 656 whites), we calculated ethnicity- and nativity-specific HL incidence rates simultaneously by age, sex, and histologic subtype, and tumor cell EBV prevalence.ResultsCompared with white rates, Hispanic HL rateswere lower overall (70 %) and for nodular sclerosis HL,particularly among young adults (6065 % for females).However, they were higher among children (200 %) andolder adults, and for mixed cellularity HL. Compared withrates in foreign-born Hispanics, rates in US-born Hispanicswere higher among young adults (>threefold in females),lower for children and adults over age 70, and consistentlyintermediate compared with rates in whites. EBV tumorprevalence was 67, 32, and 23 % among foreign-bornHispanics, US-born Hispanics, and whites, respectively,although with variation by age, sex, and histology.ConclusionsFindings strongly implicate environmentalinfluences, such as nativity-related sociodemographic dif-ferences, on HL occurrence. In addition, lower young adultrates and higher EBV prevalence in US-born Hispanicsthan in whites raise questions about the duration/extent ofenvironmental change for affecting HL rates and also pointto ethnic differences in genetic susceptibility. Lesser variation in mixed cellularity HL rates and greater variation in rates for females across groups suggest less modifiable factors interacting with environmental influences.
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Authors: Keegan, T.H.; Yang, J.; Clarke, C.A.; Glaser, S.L.; Gomez, S.L.; Chang, E.T.
Periodical (Full): Cancer Causes Control
Issue: 6
Volume: 25
Pages: 709-725
Data Collections: IPUMS USA
Topics: Health, Race and Ethnicity
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