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Title: Maternal Influenza Vaccine and Risks for Preterm or Small for Gestational Age Birth
Citation Type: Journal Article
Publication Year: 2014
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Abstract: Objective To study the impact of influenza vaccine administered to pregnant women during all trimesters on the rates of preterm and small for gestational age (SGA) births, evaluating both increased and decreased risk. Study design This retrospective observational matched cohort study involved 7 Vaccine Safety Datalink sites across the US for the 2004-05 through 2008-09 influenza seasons. Cohort eligibility and outcomes were determined from administrative, claims, medical records, and birth data. In propensity score– and vaccine exposure time–matched analyses, ORs for preterm and SGA births were calculated. Results Among 57 554 matched vaccinated and unvaccinated pregnant women, including 16 240 women in the first trimester, maternal vaccination was not associated with increased or decreased risk for preterm birth (OR for delivery at <37 weeks gestation, 0.97 [95% CI, 0.93-1.02]; for delivery at ≤32 weeks gestation, 0.98 [95% CI, 0.86-1.12]; and for delivery at ≤34 weeks gestation, 0.96 [95% CI, 0.88-1.04]) or SGA birth (OR for <5th percentile weight for gestational age, 1.02 [95% CI, 0.96-1.09], and for <10th percentile weight for gestational age, 1.00 [95% CI, 0.96-1.04]). Similarly, first trimester vaccination was not associated with increased or decreased risk for preterm or SGA birth. Conclusion Receipt of trivalent inactivated influenza vaccine during pregnancy was not associated with increased or decreased risk of preterm or SGA birth. These findings support the safety of vaccinating pregnant women against influenza during the first, second, and third trimesters, and suggest that a nonspecific protective effect of the influenza vaccine for these outcomes does not exist.
Url: https://www.sciencedirect.com/science/article/abs/pii/S0022347614000651
User Submitted?: No
Authors: Nordin, James, D; Kharbanda, Elyse, O
Periodical (Full): The Journal of Pediatrics
Issue: 5
Volume: 164
Pages: 1051-1057
Data Collections: IPUMS Health Surveys - NHIS
Topics: Fertility and Mortality, Health
Countries: United States