Full Citation
Title: Liver Cancer: A Leading Cause of Cancer Death in the United States and the Role of the 1945–1965 Birth Cohort by Ethnicity
Citation Type: Journal Article
Publication Year: 2019
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DOI: https://doi.org/10.1016/j.jhepr.2019.05.008
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Abstract: Background and Aims: Liver cancer (LC) is highly fatal and the most rapidly increasing cancer in the United States (US), where the leading cause is chronic hepatitis C (HCV) infection, particularly prevalent among the 1945-1965 birth cohort, the so-called “baby boomers”. Focusing on this cohort-etiology link, we aim to characterize LC patterns for 15 unique US populations: White, African American, Mexican Immigrant, Mexican American, Cuban and Chinese, among others. Methods: Individual-level mortality data from 2012-2016 from the health departments of three large states - California, Florida, New York - were pooled to compute LC mortality rates for each racial/ethnic group and for two birth cohorts of interest: “1945-1965 cohort” and “older cohort”. Results: LC is a major cause of cancer death among all US male groups and the leading cause in Mexican American men. White, African American, Mexican American, and Puerto Rican males had over 50% of their age-adjusted LC mortality coming from the 1945-1965 birth cohort. In contrast, foreign-born male and all female populations had higher LC mortality originating from the older cohort. Internationally, US White male baby boomers had 49% higher LC mortality than their counterparts in Europe (MRR:1.49; 95%CI: 1.43-1.56). Conclusions: Populations burdened disproportionately by LC in the 1945-1965 cohort include US-born males who share one common phenomenon: presence in the US during the 1960s-1990s when significant HCV transmission took place; these will benefit most from HCV screening and treatment. For the others, including all women, Asian subgroups, and especially burgeoning Hispanic immigrant populations, comprehensive LC prevention efforts will require detailed study of the distribution of LC etiology, including HCV, but also NAFLD, alcoholic liver disease, etc.
Url: https://www.sciencedirect.com/science/article/pii/S2589555919300564
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Authors: Pinheiro, Paulo, S; Callahan, Karen, E; Jones, Patricia, D; Morris, Cyllene; Ransdell, Justine, M; Kwon, Deukwoo; Brown, Clyde, P; Kobetz, Erin, N
Periodical (Full): JHEP Reports
Issue: 3
Volume: 1
Pages: 162-169
Data Collections: IPUMS USA
Topics: Fertility and Mortality, Health, Race and Ethnicity
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