This paper develops a theory of large corporate headquarters’ location in post-industrial capitalism. It posits that human capital has become the primary factor in the location decisions of large corporate headquarters. It argues that such operations will locate in skilled cities that are also larger and globally connected. These hypotheses are tested using data from the Fortune 500 between 1955 and 2017. Count models are estimated to test the relative importance of human capital, population size and airport connectivity, alongside taxation and other factors identified in the relevant literature. The findings are consistent with the hypotheses.