Background: Although substantial research has recognized the extensive prevalence of domestic violence in developing world, little is identified about particular risk and protective factors. Literature has ample evidence that child marriage and women empowerment are linked with domestic violence but the association is context specific. This study analyzes the association between child marriage and domestic violence in a cross countries context. Method: The study is based on data extracted from Demographic and Health Survey (DHS) and has been taken from the Integrated Public Use Microdata Series (IPUMS) database. Total observations are (N=324,952) came from 18 countries of Middle East, Africa and South Asia. Adjusted and unadjusted “Multivariate Logistic Regression Models” are used to determine the impact of child marriage on domestic violence. In addition, mediation analysis are done which explores the pathways through which child marriage affects domestic violence. Results: Among all the countries, rate of child marriage is lowest in Rwanda (2014) that is 16.1% and highest in Bangladesh (2007) that is 83.3%. Percentage of violence is lowest in Burkina Faso (2010) that is 10.6% and highest in Congo Democratic Republic (2007) that is 54.7%.Child marriage increases the odds of domestic violence (OR = 1.145; 95% CI = 1.107 - 1.185; p< 0.001). Women married in their childhood are 14.5% more likely to face domestic violence as compared to women not married in their childhood One of the Counterintuitive result of our multivariate logit model is that more empowered women are 8.6% more likely to face domestic violence than women not empowered, (OR = 1.086; 95% CI = 1.041 - 1.132; p< 0.001). The indirect mediating effect of violence was 8.22% of the total effect of child marriage on the domestic violence (P < 0.000). The indirect mediating effect of woman’s empowerment was negative 4% of the total effect of child marriage on the domestic violence (P < 0.000). Conclusion: Child marriage is significantly a risk factor against domestic violence. Our results suggest that a decrease in the rate of child marriage make women less obliging of domestic violence, which ultimately as a consequence to make them reuse to acceptance of domestic violence. Also, an increase in women’s level of education make them less prospective to face domestic violence because increase in their educational level will increase their bargaining power. Through better educational policies it needs to change the women’s attitude against acceptance of domestic violence.